M Martin
Osiris Therapeutics Inc., USA
Biography
Marc Martin was born on 02/09/1959 in Antwerp and Currently working as an Deputy chief medical services, CHU Brugmann, Brussels
Abstract
Background. Previous investigations have proved that the use of differential temperature evolution as “energetic” feedback for monitoring the insulin treatment of severe hyperglycemia, was not worse and may be better than the classical schema, independently on the pathology leading to this glucose metabolism disorder. Nevertheless, some cases of hypoglycemia were still recorded.
The aim of the present work was to elaborate, and to test in experiments (and clinics?) a device which will be able to preview and correct the hypoglycemia development.
Material and methods. For the device elaboration with digital thermic sensors for body deep and superficial temperature registration, Atmel AVR processor, TFT touchscreen and injection pumps for insulin and glucose automated injection was used. The device was tested in observation and treatment regimens in 30 rats, 5 informed healthy volunteers and 10 informed patients. During the procedures body and room, temperatures were registered by the device and usual thermometer, peripheral glycemia was measured by strips (One Touch, Switzerland).
Results. In observation regimen, the device was able to detect temperature events predicting a hypoglycemia in animals and glucose metabolism disorder in humans. In treatment regimen in rats with Streptozotocin-induced diabetes, a quick normalization of glycemia could be reached by insulin injection, as well as a correction of temperature fall by glucose injection.
Conclusion. These first results have shown that it is possible to automate the treatment of severe acute glucose metabolism disorders by both insulin and glucose injection based on the evolution of body temperatures as a feedback. Further investigations are still necessary to confirm the device possibilities, particularly for chronic glucose disorders.